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Expert advice on colorectal cancer risk and screening tools

In our new Clinical Practice Update, experts provide nine pieces of guidance on risk stratification for CRC screening and post-polypectomy surveillance.
Colon Cancer concept
Colon Cancer concept

Despite the decline in colorectal cancer (CRC) mortality over the past two decades, CRC remains the second leading cause of cancer deaths in the U.S. 

While most cases of CRC are sporadic and increase with older age, screening is recommended for average-risk adults starting at age 45. Risk stratification for beginning CRC screening should take into account age, family history, predisposing hereditary CRC syndromes, prior screening and other CRC predisposing factors. 

Author Dr. Rachel Issaka highlights 5 key takeaways when it comes to understanding your patients’ risk for colorectal cancer.

Who is considered average risk?

  • All individuals without a personal or family history of CRC, inflammatory bowel disease, hereditary CRC syndromes or other CRC predisposing conditions 

Who is considered at an increased risk?

  • All individuals with a first-degree relative diagnosed with CRC, particularly before the age of 50 
  • All individuals with a personal or family history of CRC, inflammatory bowel disease, hereditary CRC syndromes or other CRC predisposing conditions 

Best practice advice

  • Screening options for individuals at average risk for CRC include colonoscopy, fecal immunochemical test, flexible sigmoidoscopy plus fecal immunochemical test, multitarget stool DNA fecal immunochemical test and CT colonography.

  • Colonoscopy should be the screening tool used for individuals at an increased risk for CRC.

  • Screening for average risk individuals should begin at age 45. Screening for increased risk individuals should begin at age 40 or 10 years before the age of diagnosis of the youngest affected relative, whichever comes first.

  • The decision to continue CRC screening in individuals older than 75 years should be individualized, based on an assessment of risks, benefits, screening history and comorbidities.

Read the full AGA Clinical Practice Update on Risk Stratification for Colorectal Cancer Screening and Post-Polypectomy Surveillance: Expert Review, published in the November issue of Gastroenterology.   

See the full 9 best practice advice statements on our clinical guidance page. 

AGA clinical guidance

Find the latest evidence-based recommendations for treating your patients.

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