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Watch the inaugural Gastro Journal Club

Dr. Loren Laine leads a discussion with residents on head-to-head PPI trials for erosive esophagitis.
Participants in the inaugural Gastro Journal Club
Participants in the inaugural Gastro Journal Club

The inaugural Gastro Journal Club, developed by editors-in-chief Drs. Paul Moayyedi and David Weinberg, kicked off earlier this month with a group of residents from McMaster University. The Gastro Journal Club was created by residents and fellows for the opportunity to meet and talk with authors about their recently published work in Gastroenterology. If you are interested in arranging a Gastro Journal Club session at your institution, please contact [email protected].

The discussion featured a presentation from Dr. Loren Laine on his paper, “Vonoprazan Versus Lansoprazole for Healing and Maintenance of Healing of Erosive Esophagitis: A Randomized Trial,” that was published in the January 2023 issue of Gastroenterology.

Dr. Laine is Professor of Medicine (Digestive Diseases); Chief, Section of Digestive Diseases, Internal Medicine; and Medical Chief, Digestive Health, at Yale School of Medicine. He also served as the 107th president of AGA from 2012-2013.

Outline of the meeting:

[0:00] Introduction

[4:35] Article discussion

[27:14] Why did the authors see a need for this particular trial?

[30:38] Thoughts on the dosing of the medication between treatment groups and reports of adverse events

[32:37] Recommendations on switching to a lower dose of vonoprazan during the maintenance phase of treatment

[34:00] Why did the authors select lansoprazole as the comparator in this study?

[39:00] Efficacy of vonoprazan in treating different grades of esophagitis

[41:00] What is the place of vonoprazan in clinical practice if it is approved for gastroesophageal reflux disease?

[43:03] Final thoughts

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