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Experts release new recommendations for hamartomatous polyposis syndrome

The U.S. Multisociety Task Force on CRC has 14 recommendations on genetic evaluation, surveillance and treatment best practices.
Multi-Society Task Force Logos
Multi-Society Task Force Logos

The U.S. Multisociety Task Force on Colorectal Cancer has released new guidance for the diagnosis and management of patients with rare hamartomatous polyposis syndromes with a focus on endoscopic management.

Key takeaway

The U.S. Multisociety Task Force on Colorectal Cancer recommends patients with two or more lifetime hamartomatous polyps, a family history of hamartomatous polyps, or a cancer associated with a hamartomatous polyposis syndrome in first or second-degree relative undergo genetic evaluation. If the patient and doctor determine genetic testing is warranted, it should be performed using a multigene panel test.

The 14 recommendations in this new guidance document provide genetic evaluation guidance for patients with hamartomatous polyps as well as surveillance and treatment best practices. This new guidance is provided by the U.S. Multisociety Task Force on Colorectal Cancer, which is comprised of leading experts representing the American College of Gastroenterology (ACG), the American Gastroenterological Association (AGA) and the American Society for Gastrointestinal Endoscopy (ASGE).

For more information, review the full publication: Diagnosis and Management of Cancer Risk in the Gastrointestinal Hamartomatous Polyposis Syndromes: Recommendations of the US Multi-Society Task Force on Colorectal Cancer. These recommendations are published jointly in GastroenterologyThe American Journal of Gastroenterology, and Gastrointestinal Endoscopy.


  • C. Richard Boland, MD, University of California-San Diego School of Medicine, San Diego, California
  • Gregory E. Idos, MD, MS, Center for Precision Medicine, City of Hope National Medical Center, Duarte, California
  • Carol Dumo, MD, Sinai Health The Zane Cohen Centre for Digestive Diseases, The Mount Sinai Hospital, Toronto, Ontario
  • Francis M. Giardiello, MD, The Johns Hopkins University School of Medicine, Baltimore, Maryland
  • Jason A. Dominitz, MD, MHS, Veterans Affairs Puget Sound Health Care System, Seattle, Washington
  • Seth Gross, MD, New York University Langone Health, New York, New York
  • Brian C. Jacobson, MD, MPH, Massachusetts General Hospital, Boston, Massachusetts
  • Swati G. Patel, MD, University of Colorado School of Medicine, Rocky Mountain Regional Veterans Affairs Medical Center, Aurora, Colorado
  • Aasma Shaukat, MD, MPH, Minneapolis VA Health Care System, Minnesota
  • Douglas J. Robertson, MD, MPH, Dartmouth Geisel School of Medicine, Hanover, New Hampshire
  • Joseph C. Anderson, MD, MHCDS, Dartmouth Geisel School of Medicine, Hanover, New Hampshire
  • Carol A. Burke, MD, Cleveland Clinic, Cleveland, Ohio
  • Samir Gupta, MD, MSc, University of California San Diego, San Diego, California
  • Sapna Syngal, MD, MPH, Dana-Farber Cancer Institute, Boston, Massachusetts
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