Emerging technologies may significantly alter how we perform endoscopy and serve as adjunctive approaches to impact key quality measures in Barrett’s esophagus (BE) patients including neoplasia detection rate (NDR)/dysplasia detection rate (DDR) and post-endoscopy esophageal adenocarcinoma (PEEC) rates. However, in the short term, improving upper endoscopy quality will rely on well-trained and vigilant endoscopists rather than technology enhancements. The practice of high-quality upper endoscopy is critically important to the success of any BE screening or surveillance program designed to reduce the incidence and mortality associated with PEEC and esophageal adenocarcinoma (EAC).