AGA Family of Websites: Gastro.org
Guideline

Pharmacological interventions for adults with obesity

Nine clinical recommendations guide the use of approved medications to treat adults with obesity.

Guideline Tool kits

Members only access the guideline tool kits

Recommendations

1. In adults with obesity or overweight with weight-related complications, who have an inadequate response to lifestyle interventions, AGA recommends adding pharmacological agents to lifestyle interventions over continuing lifestyle interventions alone.*

2. In adults with obesity or overweight with weight-related complications, AGA suggests using semaglutide 2.4 mg with lifestyle interventions, compared with lifestyle interventions alone.*

3. In adults with obesity or overweight with weight-related complications, AGA suggests using liraglutide 3.0 mg with lifestyle interventions, compared with lifestyle interventions alone.*

4. In adults with obesity or overweight with weight-related complications, AGA suggests using phentermine-topiramate ER with lifestyle modifications, compared with lifestyle modifications alone.*

5. In adults with obesity or overweight with weight-related complications, AGA suggests using naltrexone-bupropion ER with lifestyle modifications, compared with lifestyle modifications alone.*

6. In adults with obesity or overweight with weight-related complications, AGA suggests against the use of orlistat.*

7. In adults with obesity or overweight with weight-related complications, AGA suggests using phentermine with lifestyle modifications, compared with lifestyle modifications alone.*

8. In adults with obesity or overweight with weight-related complications, AGA suggests using diethylpropion with lifestyle modifications, compared with lifestyle modifications alone.*

9. In adults with BMI between 25 and 40 kg/m2, AGA recommends using Gelesis100 oral superabsorbent hydrogel only in the context of a clinical trial.

*Recommendation includes additional implementation considerations.

Resources

Your hub for GI education

Discover upcoming events, webinars and other education to stay current with advances in the GI field.

X