AGA Family of Websites: Gastro.org
Guideline

Pharmacological interventions for adults with obesity

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Nine clinical recommendations guide the use of approved medications to treat adults with obesity.

Guideline Tool kits

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Recommendations

1. In adults with obesity or overweight with weight-related complications, who have an inadequate response to lifestyle interventions, AGA recommends adding pharmacological agents to lifestyle interventions over continuing lifestyle interventions alone.*

2. In adults with obesity or overweight with weight-related complications, AGA suggests using semaglutide 2.4 mg with lifestyle interventions, compared with lifestyle interventions alone.*

3. In adults with obesity or overweight with weight-related complications, AGA suggests using liraglutide 3.0 mg with lifestyle interventions, compared with lifestyle interventions alone.*

4. In adults with obesity or overweight with weight-related complications, AGA suggests using phentermine-topiramate ER with lifestyle modifications, compared with lifestyle modifications alone.*

5. In adults with obesity or overweight with weight-related complications, AGA suggests using naltrexone-bupropion ER with lifestyle modifications, compared with lifestyle modifications alone.*

6. In adults with obesity or overweight with weight-related complications, AGA suggests against the use of orlistat.*

7. In adults with obesity or overweight with weight-related complications, AGA suggests using phentermine with lifestyle modifications, compared with lifestyle modifications alone.*

8. In adults with obesity or overweight with weight-related complications, AGA suggests using diethylpropion with lifestyle modifications, compared with lifestyle modifications alone.*

9. In adults with BMI between 25 and 40 kg/m2, AGA recommends using Gelesis100 oral superabsorbent hydrogel only in the context of a clinical trial.

*Recommendation includes additional implementation considerations.

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