1. Traditional laxatives
a. In patients with opioid-induced constipation (OIC), AGA recommends use of laxatives as first-line agents.
2. Peripherally acting μ-opioid receptor antagonists (PAMORAs)
a. In patients with laxative refractory OIC, AGA recommends naldemedine over no treatment.
b. In patients with laxative refractory OIC, AGA recommends naloxegol over no treatment.
c. In patients with laxative refractory OIC, AGA suggests methylnatrexone over no treatment.
3. Intestinal secretagogues
a. In patients with OIC, AGA makes no recommendation for the use of lubiprostone.
4. Selective 5-HT agonists
a. In patients with OIC, AGA makes no recommendation for the use of prucalopride.
