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Guideline

Gastrointestinal evaluation of iron deficiency anemia

Treatment protocol for the initial diagnosis and GI evaluation of iron deficiency anemia (IDA).

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Recommendations

1. In patients with anemia, AGA recommends using a cutoff of 45 ng/mL over 15 ng/mL when using ferritin to diagnose iron deficiency.

2. In asymptomatic postmenopausal women and men with iron deficiency anemia, AGA recommends bidirectional endoscopy over no endoscopy.

3. In asymptomatic premenopausal women with iron deficiency anemia, AGA suggests bidirectional endoscopy over iron replacement therapy only.

4. In patients with iron deficiency anemia without other identifiable etiology after bidirectional endoscopy, AGA suggests noninvasive testing for Helicobacter pylori, followed by treatment if positive, over no testing.
5. In patients with iron-deficiency anemia, AGA suggests against the use of routine gastric biopsies to diagnose atrophic gastritis.

6. In asymptomatic adult patients with iron deficiency anemia and plausible celiac disease, AGA suggests initial serologic testing, followed by small bowel biopsy only if positive, over routine small bowel biopsies.

7. In uncomplicated asymptomatic patients with iron deficiency anemia and negative bidirectional endoscopy, AGA suggests a trial of initial iron supplementation over the routine use of video capsule endoscopy.

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