1. In patients without a personal history of colorectal or another cancer but with a family history suggestive of Lynch syndrome, AGA suggests that risk prediction models be offered rather than doing nothing.
2. In patients without a personal history of colorectal or another cancer but with a family history suggestive of Lynch syndrome, AGA suggests that risk prediction models be offered rather than proceeding directly with germline genetic testing.
3. AGA recommends testing the tumors of all patients with colorectal cancer with either immunohistochemistry (IHC) or for microsatellite instability (MSI) to identify potential cases of Lynch syndrome versus doing no testing for Lynch syndrome.
4. AGA suggests that in patients with colorectal cancer with IHC absent for MLH1, second-stage tumor testing for a BRAF mutation or for hypermethylation of the MLH1 promoter should be performed rather than proceeding directly to germline genetic testing.
5. AGA recommends surveillance colonoscopy (versus doing nothing) in persons with Lynch syndrome.
6. AGA suggests that surveillance colonoscopy should be performed every 1 to 2 years versus less frequent intervals.
7. AGA suggests that aspirin be offered for cancer prevention in patients with Lynch syndrome.
