Cyclic vomiting syndrome (CVS) is a chronic disorder of gut–brain interaction characterized by acute episodes of nausea, vomiting, and retching, separated in time by episode-free periods. Individuals with CVS can identify a stereotypic pattern of symptoms that present during both the prodromal and emetic phases. Although there are effective treatments for most patients, the condition remains underdiagnosed and thus undertreated. Most patients experience years of diagnostic delays, extensive and futile investigations, and even unnecessary surgical procedures. Approximately one-half of people with CVS visit the emergency department (ED) at least annually, and 1 in 3 adults with CVS will become disabled.2 Access to care, early recognition of CVS, and appropriate treatment can reduce CVS symptoms, reduce health care utilization, and improve patients’ quality of life.
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